Sonic's Secrets: Clue.

Fed up of waiting for the computer players to take their turn? Here's how to get a 2 player game...

Select 3 players, the lowest number allowed, and assign the third player as a 'spare' human player. When the game starts immediatly make an accusation using the 'spare' player and they will be disqualified. You can now continue with just 2 players.